Full metadata record
DC Field | Value | Language |
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dc.creator | Romero-Torrecilla, J.A. (Juan Antonio) | - |
dc.creator | Lamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María) | - |
dc.creator | Ripalda-Cemboráin, P. (Purificación) | - |
dc.creator | López-Martínez, T. (Tania) | - |
dc.creator | Abizanda-Sarasa, G. (Gloria) | - |
dc.creator | Riera-Alvarez, L. (Luis) | - |
dc.creator | Ruiz-de-Galarreta-Moriones, S.(Sergio) | - |
dc.creator | López-Barberena, A. (Asier) | - |
dc.creator | Rodriguez-Florez, N. (Naiara) | - |
dc.creator | Elizalde, R. (Reyes) | - |
dc.creator | Jayawarna, V. (Vineetha) | - |
dc.creator | Valdés-Fernández, J. (José) | - |
dc.creator | Echanove-González De Anleo, M. (Miguel) | - |
dc.creator | Childs, P. (Peter) | - |
dc.creator | Juan-Pardo, E.M. (Elena M.) de | - |
dc.creator | Salmeron-Sanchez, M. (Manuel) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.creator | Muiños-López, E. (Emma) | - |
dc.creator | Granero-Moltó, F. (Froilán) | - |
dc.date.accessioned | 2023-11-15T16:14:15Z | - |
dc.date.available | 2023-11-15T16:14:15Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Romero-Torrecilla, J. (Juan Antonio); Lamo de Espinosa-Vázquez de Sola, J. (José María); Ripalda-Cemboráin, P. (Purificación); et al. "An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration". NPJ regenerativa medicine. 8 (1), 2023, 54 | es |
dc.identifier.issn | 2057-3995 | - |
dc.identifier.uri | https://hdl.handle.net/10171/67857 | - |
dc.description.abstract | During bone regeneration, the periosteum acts as a carrier for key regenerative cues, delivering osteochondroprogenitor cells and crucial growth factors to the injured bone. We developed a biocompatible, 3D polycaprolactone (PCL) melt electro-written membrane to act as a mimetic periosteum. Poly (ethyl acrylate) coating of the PCL membrane allowed functionalization, mediated by fibronectin and low dose recombinant human BMP-2 (rhBMP-2) (10-25 mu g/ml), resulting in efficient, sustained osteoinduction in vitro. In vivo, rhBMP-2 functionalized mimetic periosteum demonstrated regenerative potential in the treatment of rat critical-size femoral defects with highly efficient healing and functional recovery (80%-93%). Mimetic periosteum has also proven to be efficient for cell delivery, as observed through the migration of transplanted periosteum-derived mesenchymal cells to the bone defect and their survival. Ultimately, mimetic periosteum demonstrated its ability to deliver key stem cells and morphogens to an injured site, exposing a therapeutic and translational potential in vivo when combined with unprecedentedly low rhBMP-2 doses. | - |
dc.description.sponsorship | This work was supported by funds of the Ministerio de Ciencia e Investigación through Instituto de Salud Carlos III and European Regional Development Funds (A way to make Europe) (PI17/00136, PI20/00076) to F.G.M. and ISC-RETICS (RD16/0011/ 005) and Next Generation EU, Plan de Recuperación, Transformación y Resiliencia RICORS TERAV ISCIII (RD21/0017/0009) and European Union Horizon 2020 MSCA-RISE (grant agreement #872648, MEPHOS) to F.P., European Union Horizon 2020 program (grant agreement #874889, HEALIKICK) to M.S.S. and F.G.M., EPSRC Programme grant (EP/P001114/1) to M.S.-S. and Departamento de Desarrollo Económico del Gobierno de Navarra (PC009-010-011 and PC073-074-075, 3DMedical) to F.G.M. J.A. RomeroTorrecilla was supported by a fellowship of “Asociación de Amigos de la Universidad de Navarra” and “Obra Social La Caixa”; the research leading to these results received funding from “la Caixa” Banking Foundation. J.V.F. was supported by a fellowship from “Asociación de Amigos de la Universidad de Navarra”, and M.E.G.A. is supported by a CIMA AC fellowship from “Fundación para la Investigación Médica Aplicada”. | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Área de Biomedicina | - |
dc.subject | Induced membrane technique. | - |
dc.subject | Growth-factor delivery. | - |
dc.subject | Stem-cells. | - |
dc.subject | Morphogenetic protein-2. | - |
dc.subject | Biomimetic periosteum. | - |
dc.subject | Defects. | - |
dc.subject | BMP-2 | - |
dc.subject | Rat. | - |
dc.subject | Model | - |
dc.subject | Differentiation | - |
dc.title | An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration | - |
dc.type | info:eu-repo/semantics/article | - |
dc.relation.publisherversion | https://pubmed.ncbi.nlm.nih.gov/37773177/ | - |
dc.editorial.note | This article is licensed under a Creative Commons Attribution 4.0 International License. | - |
dc.identifier.doi | 10.1038/s41536-023-00330-2 | - |
dadun.citation.number | 1 | - |
dadun.citation.publicationName | NPJ regenerative medicine | - |
dadun.citation.startingPage | 54 | - |
dadun.citation.volume | 8 | - |
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