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dc.creatorTeijeira, A. (Álvaro)-
dc.creatorHunter, M.C. (Morgan C.)-
dc.creatorRusso, E. (Erica)-
dc.creatorProulx, S.T. (Steven T.)-
dc.creatorFrei, T. (Thomas)-
dc.creatorDebes, G.F. (Grudun F.)-
dc.creatorColes, M. (Marc)-
dc.creatorMelero, I. (Ignacio)-
dc.creatorDetmar, M. (Michael)-
dc.creatorRouzaut, A. (Ana)-
dc.creatorHalin, C. (Cornelia)-
dc.date.accessioned2024-01-19T10:30:24Z-
dc.date.available2024-01-19T10:30:24Z-
dc.date.issued2017-
dc.identifier.citationTeijeira, A. (Álvaro); Hunter, M.C. (Morgan C.); Russo, E. (Erica); et al. "T cell migration from inflamed skin to draining lymph nodes requires intralymphatic crawling supported by ICAM-1/LFA-1 interactions". Cell reports. 18 (4), 2017, 857 - 865es
dc.identifier.issn2211-1247-
dc.identifier.urihttps://hdl.handle.net/10171/68437-
dc.description.abstractT cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo. T cells entered into and actively migrated within lymphatic capillaries but were passively transported in contractile collecting vessels. Intralymphatic T cell number and motility were increased during contact-hypersensitivity-induced inflammation and dependent on ICAM-1/LFA-1 interactions. In vitro, blockade of endothelial cell-expressed ICAM-1 reduced T cell adhesion, crawling, and transmigration across lymphatic endothelium and decreased T cell advancement from capillaries into lymphatic collectors in skin explants. In vivo, T cell migration to draining lymph nodes was significantly reduced upon ICAM-1 or LFA-1 blockade. Our findings indicate that T cell migration through LVs occurs in distinct steps and reveal a key role for ICAM-1/LFA-1 interactions in this process.es_ES
dc.description.sponsorshipA.T. was supported by a fellowship from the Swiss Government Excellence Scholarship Program. C.H. gratefully acknowledges financial support from the Swiss National Science Foundation (grant 310030_156269).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectLymphatic vesselses_ES
dc.subjectIntravital microscopyes_ES
dc.subjectT celles_ES
dc.subjectCell migrationes_ES
dc.subjectInflammationes_ES
dc.subjectICAM-1es_ES
dc.titleT cell migration from inflamed skin to draining lymph nodes requires intralymphatic crawling supported by ICAM-1/LFA-1 interactionses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).es_ES
dc.identifier.doi10.1016/j.celrep.2016.12.078-
dadun.citation.endingPage865es_ES
dadun.citation.number4es_ES
dadun.citation.publicationNameCell reportses_ES
dadun.citation.startingPage857es_ES
dadun.citation.volume18es_ES
dc.identifier.pmid28122237-

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