Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Teijeira, A. (Álvaro) | - |
dc.creator | Hunter, M.C. (Morgan C.) | - |
dc.creator | Russo, E. (Erica) | - |
dc.creator | Proulx, S.T. (Steven T.) | - |
dc.creator | Frei, T. (Thomas) | - |
dc.creator | Debes, G.F. (Grudun F.) | - |
dc.creator | Coles, M. (Marc) | - |
dc.creator | Melero, I. (Ignacio) | - |
dc.creator | Detmar, M. (Michael) | - |
dc.creator | Rouzaut, A. (Ana) | - |
dc.creator | Halin, C. (Cornelia) | - |
dc.date.accessioned | 2024-01-19T10:30:24Z | - |
dc.date.available | 2024-01-19T10:30:24Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Teijeira, A. (Álvaro); Hunter, M.C. (Morgan C.); Russo, E. (Erica); et al. "T cell migration from inflamed skin to draining lymph nodes requires intralymphatic crawling supported by ICAM-1/LFA-1 interactions". Cell reports. 18 (4), 2017, 857 - 865 | es |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://hdl.handle.net/10171/68437 | - |
dc.description.abstract | T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo. T cells entered into and actively migrated within lymphatic capillaries but were passively transported in contractile collecting vessels. Intralymphatic T cell number and motility were increased during contact-hypersensitivity-induced inflammation and dependent on ICAM-1/LFA-1 interactions. In vitro, blockade of endothelial cell-expressed ICAM-1 reduced T cell adhesion, crawling, and transmigration across lymphatic endothelium and decreased T cell advancement from capillaries into lymphatic collectors in skin explants. In vivo, T cell migration to draining lymph nodes was significantly reduced upon ICAM-1 or LFA-1 blockade. Our findings indicate that T cell migration through LVs occurs in distinct steps and reveal a key role for ICAM-1/LFA-1 interactions in this process. | es_ES |
dc.description.sponsorship | A.T. was supported by a fellowship from the Swiss Government Excellence Scholarship Program. C.H. gratefully acknowledges financial support from the Swiss National Science Foundation (grant 310030_156269). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Lymphatic vessels | es_ES |
dc.subject | Intravital microscopy | es_ES |
dc.subject | T cell | es_ES |
dc.subject | Cell migration | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | ICAM-1 | es_ES |
dc.title | T cell migration from inflamed skin to draining lymph nodes requires intralymphatic crawling supported by ICAM-1/LFA-1 interactions | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | es_ES |
dc.identifier.doi | 10.1016/j.celrep.2016.12.078 | - |
dadun.citation.endingPage | 865 | es_ES |
dadun.citation.number | 4 | es_ES |
dadun.citation.publicationName | Cell reports | es_ES |
dadun.citation.startingPage | 857 | es_ES |
dadun.citation.volume | 18 | es_ES |
dc.identifier.pmid | 28122237 | - |
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