Ex vivo maturation of 3D-Printed, chondrocyte-laden, polycaprolactone-based scaffolds prior to transplantation improves engineered cartilage substitute properties and integration
Keywords: 
3D bioprinting.
Additive manufacturing.
Cartilage.
Chondrogenic differentiation.
Issue Date: 
Oct-2022
Publisher: 
Sage
ISSN: 
1947-6035
Editorial note: 
Creative Commons Non Commercial CC BY-NC
Citation: 
Chiesa-Estomba, C. M., Hernáez-Moya, R., Rodiño, C., Delgado, A., Fernández-Blanco, G., Aldazabal, J., ... & Aiastui, A. (2022). Ex Vivo Maturation of 3D-Printed, Chondrocyte-Laden, Polycaprolactone-Based Scaffolds Prior to Transplantation Improves Engineered Cartilage Substitute Properties and Integration. Cartilage, 13(4), 105-118.
Abstract
The surgical management of nasal septal defects due to perforations, malformations, congenital cartilage absence, traumatic defects, or tumors would benefit from availability of optimally matured septal cartilage substitutes. Here, we aimed to improve in vitro maturation of 3-dimensional (3D)-printed, cell-laden polycaprolactone (PCL)-based scaffolds and test their in vivo performance in a rabbit auricular cartilage model.

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