Ex vivo maturation of 3D-Printed, chondrocyte-laden, polycaprolactone-based scaffolds prior to transplantation improves engineered cartilage substitute properties and integration

Chiesa-Estomba, C.M. (Carlos M.); Hernaez-Moya, R. (Raquel); Rodino, C. (Claudia); Delgado, A. (Alba); Fernández-Blanco, G. (Gonzalo); Aldazabal, J. (Javier); Paredes-Puente, J. (Jacobo); Izeta, A. (Ander); Aiastui, A. (Ana)

Authors:

Chiesa-Estomba, C.M. (Carlos M.)

Hernaez-Moya, R. (Raquel)

Rodino, C. (Claudia)

Delgado, A. (Alba)

Fernández-Blanco, G. (Gonzalo)

Aldazabal, J. (Javier)

Paredes-Puente, J. (Jacobo)

Izeta, A. (Ander)

Aiastui, A. (Ana)

Keywords:

3D bioprinting.
Additive manufacturing.
Cartilage.
Chondrogenic differentiation.

Issue Date:

Oct-2022

Publisher:

Sage

ISSN:

1947-6035

Editorial note:

Creative Commons Non Commercial CC BY-NC

Citation:

Chiesa-Estomba, C. M., Hernáez-Moya, R., Rodiño, C., Delgado, A., Fernández-Blanco, G., Aldazabal, J., ... & Aiastui, A. (2022). Ex Vivo Maturation of 3D-Printed, Chondrocyte-Laden, Polycaprolactone-Based Scaffolds Prior to Transplantation Improves Engineered Cartilage Substitute Properties and Integration. Cartilage, 13(4), 105-118.

Abstract

The surgical management of nasal septal defects due to perforations, malformations, congenital cartilage absence, traumatic defects, or tumors would benefit from availability of optimally matured septal cartilage substitutes. Here, we aimed to improve in vitro maturation of 3-dimensional (3D)-printed, cell-laden polycaprolactone (PCL)-based scaffolds and test their in vivo performance in a rabbit auricular cartilage model.

URI:

https://hdl.handle.net/10171/68839

DOI:

10.1177/19476035221127638

Appears in Collections:

DA - TECNUN - Mecánica y Materiales - Artículos de revista

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