Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Gomez-Ambrosi, J. (Javier) | - |
dc.creator | Frühbeck, G. (Gema) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.date.accessioned | 2011-04-05T10:52:53Z | - |
dc.date.available | 2011-04-05T10:52:53Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Gomez-Ambrosi J, Fruhbeck G, Martinez JA. Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin. Mol Cell Endocrinol 2001 May 15;176(1-2):85-90. | es_ES |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.uri | https://hdl.handle.net/10171/17500 | - |
dc.description.abstract | Peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) is highly expressed in brown adipose tissue (BAT) and plays an important role in adaptive thermogenesis. The aim of this study was to assess the acute effect of a β3-adrenergic agonist (Trecadrine) and leptin on the expression of PGC-1 and PPARγ2 mRNA in BAT. Trecadrine produced a marked increase (4.5-fold) in PGC-1 mRNA compared to controls (P<0.001) without changes in PPARγ2 mRNA, whereas leptin administration did not alter either PGC-1 or PPARγ2 expression. These results show that selective stimulation of the β3-adrenoceptor rapidly upregulates the expression of PGC-1 in brown adipocytes without a concomitant increase in PPARγ2. Moreover, our results show that PGC-1 and PPARγ2 expression in BAT seems not to be acutely regulated by leptin. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | PGC-1 | es_ES |
dc.subject | PPARγ2 | es_ES |
dc.subject | β3-adrenergic agonist | es_ES |
dc.subject | Uncoupling protein | es_ES |
dc.subject | Brown adipose tissue | es_ES |
dc.subject | Rat | es_ES |
dc.title | Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1016/S0303-7207(01)00451-8 | - |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.