TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle.

Marti-del-Moral, A. (Amelia); Corbalan, M. (M.S.); Martinez-Gonzalez, M.A. (Miguel Ángel); Martinez, J.A. (José Alfredo)

Authors:

Marti-del-Moral, A. (Amelia)

Corbalan, M. (M.S.)

Martinez-Gonzalez, M.A. (Miguel Ángel)

Martinez, J.A. (José Alfredo)

Keywords:

β3-adrenergic receptor
Case–control study
Recreational energy expenditure
Obesity
Trp64Arg mutation

Issue Date:

2002

Publisher:

Wiley Blackwell. The definitive version is available at www3.interscience.wiley.com

Publisher Version:

http://bit.ly/fvLc2q

ISSN:

1462-8902

Citation:

Marti A, Corbalan MS, Martinez-Gonzalez MA, Martinez JA. TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Diabetes Obes Metab 2002 Nov;4(6):428-430.

Abstract

Aim: We performed a case–control study to assess the association between obesity risk and the Trp64Arg polymorphism of the β3-adrenergic receptor gene. Methods: Obese subjects [n = 159; body mass index (BMI) > 30 kg/m2] and controls (n = 154; BMI < 25 kg/m2) were compared using multivariable logistic regression to control for potential confounders. Results: A higher obesity risk (adjusted OR: 2.98; 95% CI: 1.00–8.56; p = 0.05) was associated with the Trp64Arg polymorphism among sedentary, but not among more active people. Conclusions: Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle.

URI:

https://hdl.handle.net/10171/17786

Appears in Collections:

DA - Farmacia - CAFT - Artículos de revista
DA - Medicina - MPSP -Artículos de revista

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