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|TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle.|
|Authors: ||Marti, A. (Amelia)|
Corbalan, M. (M.S.)
Martinez-Gonzalez, M.A. (Miguel Angel)
Martinez, J.A. (José Alfredo)
|Keywords: ||β3-adrenergic receptor|
Recreational energy expenditure
|Issue Date: ||2002|
|Publisher: ||Wiley Blackwell. The definitive version is available at www3.interscience.wiley.com|
|Publisher version: ||http://bit.ly/fvLc2q|
|Citation: ||Marti A, Corbalan MS, Martinez-Gonzalez MA, Martinez JA. TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Diabetes Obes Metab 2002 Nov;4(6):428-430.|
Aim: We performed a case–control study to assess the association between obesity risk and the Trp64Arg polymorphism of the β3-adrenergic receptor gene.
Methods: Obese subjects [n = 159; body mass index (BMI) > 30 kg/m2] and controls (n = 154; BMI < 25 kg/m2) were compared using multivariable logistic regression to control for potential confounders.
Results: A higher obesity risk (adjusted OR: 2.98; 95% CI: 1.00–8.56; p = 0.05) was associated with the Trp64Arg polymorphism among sedentary, but not among more active people.
Conclusions: Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle.
|Permanent link: ||http://hdl.handle.net/10171/17786|
|Appears in Collections:||DA - Medicina - MPSP -Artículos de revista|
DA - Farmacia - CAFT - Artículos de revista
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