Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Galbete, C. (Cecilia) | - |
dc.creator | Contreras, R. (Rafael) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Guillen-Grima, F. (Francisco) | - |
dc.creator | Marti-del-Moral, A. (Amelia) | - |
dc.date.accessioned | 2013-12-09T08:37:22Z | - |
dc.date.available | 2013-12-09T08:37:22Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Galbete C, Contreras R, Martínez JA, Martínez-González MA, Guillen-Grima F, Marti A. Physical Activity and Sex Modulate Obesity Risk Linked to 3111T/C Gene Variant of the CLOCK Gene in an Elderly Population: The SUN Project. Chronobiol Int 2012;29(10):1397-1404 | es_ES |
dc.identifier.issn | 0742-0528 | - |
dc.identifier.uri | https://hdl.handle.net/10171/34618 | - |
dc.description.abstract | Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the effect of rs1801260 SNP (3111T/C) of CLOCK gene, on obesity risk and to examine their interaction with lifestyle factors in an elderly population of the SUN Project. Subjects (n=903, aged 69±6) were recruited from the SUN (“Seguimiento Universidad de Navarra”) Project. DNA was obtained from saliva and lifestyle and dietary data were collected by validated self-reported questionnaires. Genotyping was assessed by RT-PCR plus allele discrimination. A significant interaction between the 3111T/C SNP of CLOCK gene and sex for overweight/obesity risk was observed (p for interaction [Sex*CLOCK] interaction <0.001). Our results showed that women carrying the C allele of CLOCK gene had a decreased overweight/obesity risk compared to non carrier -TT- subjects (OR 0.61, 95% CI: 0.36-1.04, p=0.069). Moreover, the protective effect of the 3111T/C gene variant may be enhanced in those women with a high physical activity practice. We found that women practicing more than 16.8 METs- h/week had a significantly lower overweight/obesity risk (OR 0.36, 95%CI: 0.17-0.79, p=0.011). A significant interaction between the 3111T/C gene variant and physical activity for overweight/obesity risk was observed in women (p for [PA x CLOCK] interaction=0.015). In conclusion, it appears that physical activity levels may act as an effect modifier for overweight/obesity risk linked to the 3111T/C SNP (rs1801260) of the CLOCK gene in an elderly population of the SUN Project. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Informa Healthcare | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | CLOCK | es_ES |
dc.subject | rs1801260 | es_ES |
dc.subject | Cross-sectional study | es_ES |
dc.subject | Obesity risk | es_ES |
dc.title | Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.3109/07420528.2012.728657 | - |
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