Huerta AE, Navas-Carretero S, Prieto-Hontoria PL, Martínez JA, Moreno-Aliaga MJ. Effects of alpha-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. Obesity 2014 Dec 31
Objective: To evaluate the potential body weight lowering effects of dietary supplementation
with eicosapentaenoic acid (EPA) and α-lipoic acid separately or combined, in healthy
overweight/obese women following a hypocaloric diet.
Design and Methods: This is a short-term double-blind placebo-controlled lasted 10-weeks
study with parallel design. Of the randomized participants, 97 women received the allocated
treatment (Control, EPA (1.3 g/d of EPA), α-lipoic acid (0.3 g/d) and EPA+ α-lipoic acid (1.3
g/d + 0.3 g/d)), finishing 77 volunteers. All groups followed an energy-restricted diet of 30%
from the total energy expenditure. Body weight, anthropometric measurements, body
composition, resting energy expenditure, blood pressure, serum glucose, insulin and lipid
profile, as well as leptin and ghrelin levels, were assessed at baseline and after nutritional
Results: Body weight loss was significantly higher (P < 0.05) in those groups supplemented
with α-lipoic acid. EPA supplementation significantly attenuated (P < 0.001) the decrease in
leptin levels that occurs during weight loss. Body weight loss improved lipid and glucose
metabolism parameters, but without significant differences between groups.
Conclusion: The intervention suggests that α-lipoic acid supplementation alone or in
combination with EPA may help to promote body weight loss in healthy overweight/obese
women following energy-restricted diets.