Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment
Keywords: 
Bayley scale
SLC6A3
Epigenetics
Full-term newborns
Peripheral white blood cells
Prematurity
Preterm newborns
Issue Date: 
2018
Publisher: 
Future Medicine
ISSN: 
1750-1911
1750-192X
Citation: 
Arpón A, Milagro F.I., Laja A., Segura V., Sáenz de Pipaón M., Riezu-Boj J.I., Martínez J.A. Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment. Epigenomics 2018, 10(1): 91-103. doi: 10.2217/epi-2017-0082
Abstract
AIM: To analyze whether preterm newborns show differences in methylation patterns in comparison to full-term newborns in white blood cells. PATIENTS & METHODS: Anthropometrical, biochemical features and methylation levels of preterm newborns (n = 24) and full-term newborns (n = 22) recruited in La Paz University Hospital (Spain) were assessed at 12 months of gestational age, whereas Bayley Scale of Infant Development was evaluated at 24/36 months. RESULTS: From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors. CONCLUSION: SLC6A3 methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmental diseases in newborns.

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