Bioaccessibility and biological activity of Melissa officinalis, Lavandula latifolia and Origanum vulgare extracts: influence of an in vitro gastrointestinal digestion
Palabras clave : 
Polyphenols
Caenorhabditis elegans
Antioxidants
Lemon balm
Oregano
Lavender
Plant extract
Fecha de publicación: 
2018
Editorial : 
Elsevier
ISSN: 
1756-4646
Cita: 
Gayoso, L. (Lucía); Roxo, M. (Mariana); Cavero, R.Y. (Rita Yolanda); et al. "Bioaccessibility and biological activity of Melissa officinalis, Lavandula latifolia and Origanum vulgare extracts: influence of an in vitro gastrointestinal digestion". . 44, 2018, 146 - 154
Resumen
Melissa officinalis, Lavandula latifolia and Origanum vulgare are widely used medicinal plants and spices. Their extracts were evaluated as potential antioxidants for functional food formulations. After being submitted to an in vitro gastrointestinal digestion, all the extracts showed antioxidant activity (measured by DPPH, ABTS, FRAP, TPC). Furthermore, their main polyphenols maintained high stability. Biological activity was measured using Caenorhabditis elegans, which is a widely used model in this context. Treatments of 50 and 100 µg/mL of M. officinalis significantly attenuated juglone-induced stress in the survival assay performed; moreover, all tested concentrations decreased intracellular ROS. Lavandula latifolia and O. vulgare had no significant effect against acute stress in the survival assay, but significantly decreased ROS basal levels. GST-4 expression under juglone-induced oxidative stress was significantly down-regulated by treatment with the three plant extracts (up to 63%). Besides, similar biological activity of all digested extracts was demonstrated in all in vivo assays.

Ficheros en este registro:
Fichero: 
Manuscript_celegans_dadun.pdf
Descripción: 
Tamaño: 
431 kB
Formato: 
Adobe PDF
Embargo: 
El fichero será visible a partir del 31-may-2019


Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.