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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Razquin, C. (Cristina) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Salas-Salvado, J. (Jordi) | - |
dc.creator | Estruch, R. (Ramón) | - |
dc.creator | Marti-del-Moral, A. (Amelia) | - |
dc.date.accessioned | 2010-11-17T16:07:24Z | - |
dc.date.available | 2010-11-17T16:07:24Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Razquin C, Martinez JA, Martinez-Gonzalez MA, Bes-Rastrollo M, Fernandez-Crehuet J, Marti A. A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes. Eur J Nutr (2010) 49, 5:311-319. | es_ES |
dc.identifier.issn | 1436-6207 | - |
dc.identifier.uri | https://hdl.handle.net/10171/14168 | - |
dc.description.abstract | Purpose Adiponectin gene variations have been associated with obesity. There are few interventional studies analyzing this association. The aim of this study was to analyze the effects of a nutritional intervention with Mediterranean-style diet and three (-4034A/C, +45T/G and +276 G/T) adiponectin gene variants on 3-year body weight changes in high cardiovascular risk patients Subjects and methods A total of 737 participants, aged 55-80 at high cardiovascular risk were assigned to a low-fat diet or to a Mediterranean-style diet (MD) groups, one with high intake of virgin olive oil (VOO) and the other with high intake of nuts. Anthropometric parameters were taken at baseline and after 3-year follow-up, and the genotyping of the -4034A/C, +45T/G and +276 G/T polymorphisms was done. Results GG genotype of the +45T/G polymorphism was associated with 3-year higher body weight gain (B=1.399; B=0.043). TT genotype of the +276G/T polymorphism was linked to the highest 3-year body weight gain in men. Both Mediterranean diets appeared to reverse this effect (p for interaction=0.053). Conclusion Adiponectin gene variation appeared to be associated with 3-year body weight changes in a high cardiovascular risk population. This association may be modulated by a nutritional intervention with a Mediterranean-style diet. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Dieta mediterránea | es_ES |
dc.subject | Adiponectina | es_ES |
dc.subject | Mediterranean diet | es_ES |
dc.subject | Peso corporal | es_ES |
dc.subject | Body weight | es_ES |
dc.title | A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | https://doi.org/10.1007/s00394-009-0090-2 | es_ES |
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