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dc.creatorRazquin, C. (Cristina)-
dc.creatorMartinez, J.A. (José Alfredo)-
dc.creatorMartinez-Gonzalez, M.A. (Miguel Ángel)-
dc.creatorSalas-Salvado, J. (Jordi)-
dc.creatorEstruch, R. (Ramón)-
dc.creatorMarti-del-Moral, A. (Amelia)-
dc.identifier.citationRazquin C, Martinez JA, Martinez-Gonzalez MA, Bes-Rastrollo M, Fernandez-Crehuet J, Marti A. A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes. Eur J Nutr (2010) 49, 5:311-319.es_ES
dc.description.abstractPurpose Adiponectin gene variations have been associated with obesity. There are few interventional studies analyzing this association. The aim of this study was to analyze the effects of a nutritional intervention with Mediterranean-style diet and three (-4034A/C, +45T/G and +276 G/T) adiponectin gene variants on 3-year body weight changes in high cardiovascular risk patients Subjects and methods A total of 737 participants, aged 55-80 at high cardiovascular risk were assigned to a low-fat diet or to a Mediterranean-style diet (MD) groups, one with high intake of virgin olive oil (VOO) and the other with high intake of nuts. Anthropometric parameters were taken at baseline and after 3-year follow-up, and the genotyping of the -4034A/C, +45T/G and +276 G/T polymorphisms was done. Results GG genotype of the +45T/G polymorphism was associated with 3-year higher body weight gain (B=1.399; B=0.043). TT genotype of the +276G/T polymorphism was linked to the highest 3-year body weight gain in men. Both Mediterranean diets appeared to reverse this effect (p for interaction=0.053). Conclusion Adiponectin gene variation appeared to be associated with 3-year body weight changes in a high cardiovascular risk population. This association may be modulated by a nutritional intervention with a Mediterranean-style diet.es_ES
dc.subjectDieta mediterráneaes_ES
dc.subjectMediterranean dietes_ES
dc.subjectPeso corporales_ES
dc.subjectBody weightes_ES
dc.titleA 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight changees_ES

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