Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Murillo, O. (Oihana) | - |
dc.creator | Dubrot, J. (Juan) | - |
dc.creator | Palazon, A. (Asís) | - |
dc.creator | Arina, A. (Ainhoa) | - |
dc.creator | Azpilicueta, A. (Arantza) | - |
dc.creator | Alfaro, C. (Carlos) | - |
dc.creator | Solano, S. (Sarai) | - |
dc.creator | Ochoa, M.C. (María Carmen) | - |
dc.creator | Berasain, C. (Carmen) | - |
dc.creator | Gabari, I. (Izaskun) | - |
dc.creator | Perez-Gracia, J.L. (Jose Luis) | - |
dc.creator | Berraondo, P. (Pedro) | - |
dc.creator | Hervas-Stubbs, S. (Sandra) | - |
dc.creator | Melero, I. (Ignacio) | - |
dc.date.accessioned | 2012-04-24T15:50:52Z | - |
dc.date.available | 2012-04-24T15:50:52Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Murillo O, Dubrot J, Palazon A, Arina A, Azpilikueta A, Alfaro C, et al. In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb. Eur J Immunol 2009 Sep;39(9):2424-2436. | es_ES |
dc.identifier.issn | 1521-4141 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21772 | - |
dc.description.abstract | Anti-CD137 mAb are capable of inducing tumor rejection in several syngeneic murine tumor models and are undergoing clinical trials for cancer. The anti-tumor effect involves co-stimulation of tumor-specific CD8(+) T cells. Whether antigen cross-presenting DC are required for the efficacy of anti-CD137 mAb treatment has never been examined. Here we show that the administration of anti-CD137 mAb eradicates EG7-OVA tumors by a strictly CD8beta(+) T-cell-dependent mechanism that correlates with increased CTL activity. Ex vivo analyses to determine the identity of the draining lymph node cell type responsible for tumor antigen cross-presentation revealed that CD11c(+) cells, most likely DC, are the main players in this tumor model. A minute number of tumor cells, revealed by the presence of OVA cDNA, reach tumor-draining lymph nodes. Direct antigen presentation by tumor cells themselves also participates in anti-OVA CTL induction. Using CD11c diphtheria toxin receptor-green fluorescent protein-->C57BL/6 BM chimeric mice, which allow for sustained ablation of DC with diphtheria toxin, we confirmed the involvement of DC in tumor antigen cross-presentation in CTL induction against OVA(257-264) epitope and in the antitumor efficacy induced by anti-CD137 mAb | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-VCH Verlag Berlin | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | CD137 (4-1BB) | es_ES |
dc.subject | Cross-priming | es_ES |
dc.subject | CTL | es_ES |
dc.subject | DC | es_ES |
dc.subject | Tumor immunity | es_ES |
dc.title | In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/eji.200838958/abstract | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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