Full metadata record
DC Field | Value | Language |
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dc.creator | Grau, K. (K.) | - |
dc.creator | Cauchi, S. (Stephane) | - |
dc.creator | Claus, C. (C.) | - |
dc.creator | Astrup, A. (Arne) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.creator | MacDonald, I. (Ian) | - |
dc.creator | Klimcakova, E. (E.) | - |
dc.creator | Langin, D. (D.) | - |
dc.creator | Pedersen, O. (Oluf) | - |
dc.creator | Froguel, P. (Philippe) | - |
dc.creator | Sørensen, T.I.A (Thorkild I. A.) | - |
dc.date.accessioned | 2013-04-06T17:56:13Z | - |
dc.date.available | 2013-04-06T17:56:13Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Grau K, Cauchi S, Holst C, Astrup A, Martinez JA, Saris WH, et al. TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet. Am J Clin Nutr 2010 Feb;91(2):472-479 | es_ES |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.uri | https://hdl.handle.net/10171/28214 | - |
dc.description.abstract | BACKGROUND: Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via impaired glucagon-like peptide 1 secretion, which is stimulated more by fat than by carbohydrate ingestion. OBJECTIVE: The objective was to examine the interaction between TCF7L2 rs7903146 and dietary fat and carbohydrate [high-fat, low-carbohydrate: 40-45% of energy as fat (HF); compared with low-fat, high-carbohydrate: 20-25% of energy as fat (LF)] in obese individuals' responses to a 10-wk hypoenergetic diet (-600 kcal/d). DESIGN: European, obese participants (n = 771) were randomly assigned to receive an HF or an LF diet. Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation in percentage of REE (FatOx), homeostasis model assessed insulin release (HOMA-beta), and HOMA-insulin resistance (HOMA-IR) were determined at baseline and after the intervention; 739 individuals were genotyped for rs7903146. RESULTS: Average weight loss was 6.9 kg with the LF and 6.6 kg with the HF (difference between diets, NS) diet. Among individuals who were homozygous for the T-risk allele, those in the HF diet group experienced smaller weight losses (Deltaweight) (2.6 kg; P = 0.009; n = 622), smaller DeltaFFM (1.6 kg; P = 0.027; n = 609), smaller DeltaWC (3.3 cm; P = 0.010; n = 608), and a smaller DeltaHOMA-IR (1.3 units; P = 0.004; n = 615) than did the LF diet group. For C allele carriers, there were no differences between the HF and LF diet groups. For the HF diet group, each additional T allele was associated with a reduced loss of FM (0.67 kg; P = 0.019; n = 609). TCF7L2 rs7903146 was not associated with DeltaREE, DeltaFatOx, DeltaHOMA-beta, or dropout. CONCLUSION: Our results suggest that obese individuals who are homozygous for the TCF7L2 rs7903146 T-risk allele are more sensitive to LF than to HF weight-loss diets. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Nutrition | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Diet, reducing | es_ES |
dc.subject | Dietary carbohydrates | es_ES |
dc.subject | Dietary fats | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | TCF transcription factors | es_ES |
dc.title | TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.3945/ajcn.2009.27947 | es_ES |
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