The role of MYC and PP2A in the initiation and progression of myeloid leukemias

Pippa, R. (Raffaella); Odero, M.D. (Maria Dolores)

Authors:

Pippa, R. (Raffaella)

Odero, M.D. (Maria Dolores)

Keywords:

PP2A
MYC
Myeloid leukemia
AML
CML

Issue Date:

2020

ISSN:

2073-4409

Note:

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

Citation:

Pippa, R. (Raffaella); Odero, M.D. (Maria Dolores). "The role of MYC and PP2A in the initiation and progression of myeloid leukemias". Cells. 9 (3), 2020, 544

Abstract

The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and indirectly, regulate each other's activity. Studies in cancer suggest that targeting the MYC/PP2A network is an achievable strategy for the clinic. Here, we focus on and discuss the role of MYC and PP2A in myeloid leukemias.

URI:

https://hdl.handle.net/10171/59035

DOI:

10.3390/cells9030544

Appears in Collections:

DA - Ciencias - Bioquímica y Genética - Artículos de revista
DA - CIMA - Hemato-oncología - Leucemia aguda - Artículos de Revista

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