Full metadata record
DC Field | Value | Language |
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dc.creator | Martín-Sánchez, E. (Esperanza) | - |
dc.creator | Garcés-Latre, J.J. (Juan José) | - |
dc.creator | Maia, C. (Catarina) | - |
dc.creator | Inoges, S. (Susana) | - |
dc.creator | Lopez-Diaz-de-Cerio, A. (Ascensión) | - |
dc.creator | Carmona-Torre, F. (Francisco de A.) | - |
dc.creator | Marín-Oto, M. (Marta) | - |
dc.creator | Alegre, F. (Félix) | - |
dc.creator | Molano, E. (Elvira) | - |
dc.creator | Fernández-Alonso, M. (Miriam) | - |
dc.creator | Perez, C. (Cristina) | - |
dc.creator | Botta, C. (Cirino) | - |
dc.creator | Zabaleta, A. (Aintzane) | - |
dc.creator | Alcaide, A.B. (Ana Belén) | - |
dc.creator | Landecho, M.F. (Manuel F.) | - |
dc.creator | Rua, M. (Marta) | - |
dc.creator | Perez-Warnisher, M.T. (María Teresa) | - |
dc.creator | Blanco-Fernández, L. (Laura) | - |
dc.creator | Sarvide, S. (Sarai) | - |
dc.creator | Vilas, A. (Amaia) | - |
dc.creator | Alignani, D. (Diego) | - |
dc.creator | Moreno, C. (Cristina) | - |
dc.creator | Pineda, Í. (Íñigo) | - |
dc.creator | Sogbe, M. (Miguel) | - |
dc.creator | Argemí, J. (Josepmaria) | - |
dc.creator | Paiva, B. (Bruno) | - |
dc.creator | Yuste, J.R. (José Ramón) | - |
dc.date.accessioned | 2022-05-19T11:15:00Z | - |
dc.date.available | 2022-05-19T11:15:00Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Martín-Sánchez, E. (Esperanza); Garcés-Latre, J.J. (Juan José); Maia, C. (Catarina); et al. "Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients". Frontiers in immunology. (12), 2021, 659018 | es |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://hdl.handle.net/10171/63476 | - |
dc.description.abstract | Information on the immunopathobiology of coronavirus disease 2019 (COVID-19) is rapidly increasing; however, there remains a need to identify immune features predictive of fatal outcome. This large-scale study characterized immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using multidimensional flow cytometry, with the aim of identifying high-risk immune biomarkers. Holistic and unbiased analyses of 17 immune cell-types were conducted on 1,075 peripheral blood samples obtained from 868 COVID-19 patients and on samples from 24 patients presenting with non-SARS-CoV-2 infections and 36 healthy donors. Immune profiles of COVID-19 patients were significantly different from those of age-matched healthy donors but generally similar to those of patients with non-SARS-CoV-2 infections. Unsupervised clustering analysis revealed three immunotypes during SARS-CoV-2 infection; immunotype 1 (14% of patients) was characterized by significantly lower percentages of all immune cell-types except neutrophils and circulating plasma cells, and was significantly associated with severe disease. Reduced B-cell percentage was most strongly associated with risk of death. On multivariate analysis incorporating age and comorbidities, B-cell and non-classical monocyte percentages were independent prognostic factors for survival in training (n=513) and validation (n=355) cohorts. Therefore, reduced percentages of B-cells and non-classical monocytes are high-risk immune biomarkers for risk-stratification of COVID-19 patients. | es_ES |
dc.description.sponsorship | This work was supported by the Centro de Investigación Biomédica en Red – Área de Oncología - del Instituto de Salud Carlos III (CIBERONC; CB16/12/00369 and CB16/12/00489), Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria (FIS No. PI17/01243), Fondo Europeo de Desarrollo Regional (FEDER), Fundación BBVA, Departamento de Salud de Gobierno de Navarra (0011-3638-2020-000004), and Asociación Española Contra el Cáncer (FCAECC, Predoctoral Grant Junta Provincial Navarra). This study was supported internationally by Cancer Research UK, FCAECC and AIRC under the Accelerator Award Programme, and the European Research Council (ERC) 2015 Starting Grant (MYELOMANEXT). | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Frontiers Research Foundation | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/680200/EU | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | COVID-19 | es_ES |
dc.subject | SARS-CoV-2 | es_ES |
dc.subject | Biomarkers | es_ES |
dc.subject | Flow cytometry | es_ES |
dc.subject | Lymphopenia | es_ES |
dc.subject | Outcome | es_ES |
dc.subject | Survival | es_ES |
dc.title | Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). | es_ES |
dc.identifier.doi | 10.3389/fimmu.2021.659018 | - |
dadun.citation.number | 12 | es_ES |
dadun.citation.publicationName | Frontiers in immunology | es_ES |
dadun.citation.startingPage | 659018 | es_ES |
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