Full metadata record
DC Field | Value | Language |
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dc.creator | Lassale, C. (Camille) | - |
dc.creator | Curtis, A. (Alyscia) | - |
dc.creator | Abete, I. (Itziar) | - |
dc.creator | Schouw, Y. (Yvonne) van der | - |
dc.creator | Monique-Verschuren, W.M. (W. M.) | - |
dc.creator | Lu, Y. (Yunxia) | - |
dc.creator | Bueno-de-Mesquita, H.B. (H. Bas) | - |
dc.date.accessioned | 2023-04-05T12:06:21Z | - |
dc.date.available | 2023-04-05T12:06:21Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Lassale, C. (Camille); Curtis, A. (Alyscia); Abete, I. (Itziar); et al. "Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study". Scientific reports. 8 (1), 2018, 3290 | es |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10171/65884 | - |
dc.description.abstract | All blood cells (white blood cells [WBC], red blood cells [RBC] and platelets) can play a role in atherosclerosis. Complete blood count (CBC) is widely available in clinical practice but utility as potential risk factors for cardiovascular disease (CVD) is uncertain. Our aim was to assess the associations of pre-diagnostic CBC with incidence of CVD in 14,362 adults free of CVD and aged 47.8 (±11.7) years at baseline, followed-up for 11.4 years (992 incident cases). Cox proportional hazards regressions were used to estimate HRs and 95%CI. Comparing the top (T3) to bottom (T1) tertile, increased total WBC, lymphocyte, monocyte and neutrophil counts were associated with higher CVD risk: 1.31 (1.10; 1.55), 1.20 (1.02; 1.41), 1.21 (1.03; 1.41) and 1.24 (1.05; 1.47), as well as mean corpuscular volume (MCV: 1.23 [1.04; 1.46]) and red cell distribution width (RDW: 1.22 [1.03; 1.44]). Platelets displayed an association for count values above the clinically normal range: 1.49 (1.00; 2.22). To conclude, total and diferential WBC count, MCV, RDW and platelet count likely play a role in the aetiology of CVD but only WBC provide a modest improvement for the prediction of 10-year CVD risk over traditional CVD risk factors in a general population. | es_ES |
dc.description.sponsorship | The EPIC-NL study was funded by ‘Europe against Cancer’ Programme of the European Commission (SANCO); the Dutch Ministry of Public Health, Welfare and Sports (formerly Ministry of Welfare, Public Health and Culture); the Dutch Cancer Society; ZonMW the Netherlands Organisation for Health Research and Development; and World Cancer Research Fund (WCRF). Tey had no role in the design and conduct of the study. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Research | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Blood cells | es_ES |
dc.subject | Atherosclerosis | es_ES |
dc.subject | Complete blood count (CBC) | es_ES |
dc.subject | Cardiovascular disease (CVD) | es_ES |
dc.title | Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.identifier.doi | 10.1038/s41598-018-21661-x | - |
dadun.citation.number | 1 | es_ES |
dadun.citation.publicationName | Scientific reports | es_ES |
dadun.citation.startingPage | 3290 | es_ES |
dadun.citation.volume | 8 | es_ES |
dc.identifier.pmid | 29459661 | - |
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