TARTESSUS: A Customized Electrospun Drug Delivery System Loaded with Irinotecan for Local and Sustained Chemotherapy Release in Pancreatic Cancer

Cepeda-Franco, C. (Carmen); Mitxelena-Iribarren, O. (Oihane); Calero-Castro, F.J.(Francisco José); Astigarraga, M.(Malen); Castillo-Tuñon, J.M.(Juan Manuel); Laga, I. (Iman); Pereira, S. (Sheila); Arana-Alonso, S. (Sergio); Mujika-Garmendia, M. (Maite); Padillo-Ruiz, J. (Javier)

Keywords:

Electrospinning.
Nanofiber membrane.
Pancreatic cancer.
Drug delivery system.
Irinotecan.

Issue Date:

Feb-2023

Publisher:

MDPI

ISSN:

2306-5354

Editorial note:

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

Citation:

Cepeda-Franco, C., Mitxelena-Iribarren, O., Calero-Castro, F. J., Astigarraga, M., Castillo-Tuñon, J. M., Laga, I., ... & Padillo-Ruiz, J. (2023). TARTESSUS: A Customized Electrospun Drug Delivery System Loaded with Irinotecan for Local and Sustained Chemotherapy Release in Pancreatic Cancer. Bioengineering, 10(2), 183.

Abstract

Post-surgical chemotherapy in pancreatic cancer has notorious side effects due to the high dose required. Multiple devices have been designed to tackle this aspect and achieve a delayed drug release. This study aimed to explore the controlled and sustained local delivery of a reduced drug dose from an irinotecan-loaded electrospun nanofiber membrane (named TARTESSUS) that can be placed on the patients' tissue after tumor resection surgery. The drug delivery system formulation was made of polycaprolactone (PCL)...

URI:

https://hdl.handle.net/10171/68901

DOI:

10.3390/bioengineering10020183

Appears in Collections:

DA - CEIT -Tecnologías de Información y Comunicaciones - Artículos de revista

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