TARTESSUS: A Customized Electrospun Drug Delivery System Loaded with Irinotecan for Local and Sustained Chemotherapy Release in Pancreatic Cancer
Keywords: 
Electrospinning.
Nanofiber membrane.
Pancreatic cancer.
Drug delivery system.
Irinotecan.
Issue Date: 
Feb-2023
Publisher: 
MDPI
ISSN: 
2306-5354
Editorial note: 
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Citation: 
Cepeda-Franco, C., Mitxelena-Iribarren, O., Calero-Castro, F. J., Astigarraga, M., Castillo-Tuñon, J. M., Laga, I., ... & Padillo-Ruiz, J. (2023). TARTESSUS: A Customized Electrospun Drug Delivery System Loaded with Irinotecan for Local and Sustained Chemotherapy Release in Pancreatic Cancer. Bioengineering, 10(2), 183.
Abstract
Post-surgical chemotherapy in pancreatic cancer has notorious side effects due to the high dose required. Multiple devices have been designed to tackle this aspect and achieve a delayed drug release. This study aimed to explore the controlled and sustained local delivery of a reduced drug dose from an irinotecan-loaded electrospun nanofiber membrane (named TARTESSUS) that can be placed on the patients' tissue after tumor resection surgery. The drug delivery system formulation was made of polycaprolactone (PCL)...

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