Macronutrient-specific effect of the MTNR1B genotype on lipid levels in response to 2 year weight-loss diets

Goñi-Mateos, L. (Leticia); Sun, D. (Dianjianyi); Heianza, Y. (Yoriko); Wang, T. (Tiange); Huang, T. (Tao); Cuervo, M. (Marta); Martinez, J.A. (José Alfredo); Shang, X. (Xiaoyun); Bray, G.A. (George A.); Sacks, F.M. (Frank M.); Qi, L. (Lu)

Keywords:

Cholesterol
Clinical trials
Diet and dietary lipids
Gene-diet interaction
Genetics
High-fat diet
Lipid metabolism
Low density lipoprotein
Melatonin receptor 1B
Weight-loss intervention

Issue Date:

2018

Publisher:

American Society for Biochemistry and Molecular Biology

ISSN:

0022-2275

Note:

This is an Open Access article under the CC BY license.

Citation:

Goni, L. (Leticia); Sun, D. (Dianjianyi); Heianza, Y. (Yoriko); et al. "Macronutrient-specific effect of the MTNR1B genotype on lipid levels in response to 2 year weight-loss diets". Journal of lipid research. 59 (1), 2018, 155 - 161

Abstract

Compelling evidence indicates that lipid metabolism is in partial control of the circadian system. In this context, it has been reported that the melatonin receptor 1B (MTNR1B) genetic variant influences the dynamics of melatonin secretion, which is involved in the circadian system as a chronobiotic. The objective was to analyze whether the MTNR1B rs10830963 genetic variant was related to changes in lipid levels in response to dietary interventions with different macronutrient distribution in 722 overweight/obese subjects from the POUNDS Lost trial. We did not find a significant association between the MTNR1B genotype and changes in lipid metabolism.

URI:

https://hdl.handle.net/10171/65620

DOI:

10.1194/jlr.P078634

Appears in Collections:

DA - Farmacia - CAFT - Artículos de revista

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